The six-part series, created by The Curse of Steptoe scribe Brian Fillis, is inspired by the Tom Reynolds book Blood, Sweat and Tea and will focus on the lives of three world-weary paramedics.
Four Lions star Kayvan Novak will star as the womanising Rachid, while Game of Thrones actor Richard Madden will play handsome paramedic Ashley.
Star Stories comic Rhys Thomas and Misfits actress Amy Beth Hayes will also appear as the misanthropic Stuart and his best friend Maxine respectively.
"Channel 4's increased investment in new drama will arrive on screen in Summer 2011 with two brand new series, Naked Apes and Beaver Falls," said Channel 4's head of drama Camilla Campbell. "Irreverent and provocative comedy drama, both are set to launch a host of new and emerging talent and characters. We hope viewers will love them as much as we do."
Naked Apes will be produced by Chris Clough, whose previous credits include Skins, The Bill and Born and Bred.