The Sky Sports News presenter appears alongside James Corden, Andrew Flintoff, Jamie Redknapp and John Bishop on the Sky1 sports panel quiz.
Asked what it was like to be the only girl, Thompson told Sky Magazine: "It doesn't faze me - I work in a male-dominated industry in my day job and boys are less complicated than girls."
On being teased on the show, she added: "James refers to [my partner] Dec as 'Ant and Dec', he won't ever just call him Dec!
"And obviously the fact I'm knee high to a grasshopper is always mentioned. I take no offence - I give as good as I get."
Thompson recently admitted that she enjoyed Christine Bleakley's guest appearance on the programme because "it's nice to occasionally have another girl on the show".