The medical drama, starring Nesbitt as neuroscientist Gabriel Monroe, averaged 5.9m (25.3%) in the 9pm hour and 143k (0.8%) on +1. The programme totally outperformed Comic Relief: Famous, Rich And In the Slums, which had 3.68m (15.8%) on BBC One.
Earlier, The One Show dipped to 3.9m (17.9%) on BBC One from 7pm, while Tonight: Make Your Own School fetched 2.37m 10.3% on ITV1 from 7.30pm. Bang Goes The Winter Weather Special captivated 2.5m (10.5%) on BBC One in the 8pm hour and Question Time brought in 2.58m (20.2%) from 10.45pm.
Channel 4's Coach Trip mustered 1.8m (11.3%) from 5.30pm and 241k (1.2%) on +1. Later, Relocation, Relocation located 2.11m (8.9%) in the 8pm hour and 197k (0.8%) on timeshift. Love Thy Neighbour took 1.02m (4.4%) from 9pm and 114k (0.6%) on +1. 10'Clock Live was seen by 630k (3.6%).
Over at BBC Two, The Culture Show enchanted 660k (3%) in the 7pm hour, before A Farmers Life For Me served up 1.17m (4.9%) from 8pm. New series The British At Work mustered 1.65m (7.1%) in the 9pm hour and Mock The Week had 1.04m (5.2%) from 10pm.
Live UEFA Europa League football pulled in 2.2m (10.7%) on Channel 5 between 5.45pm and 8.15pm, before Police Interceptors grabbed 923k (3.8%). A screening of The Longest Yard rounded out the evening with 939k (4.8%).
Overall, ITV1 won primetime with 23.9% (+1: 0.5%) against BBC One's 18.3%. Channel 5 came in third with 6.5%, ahead of Channel 4 with 5.1% (+1: 0.6%) and BBC Two with 4.9%.
Elsewhere, Celebrity Juice amused 1.33m (7.1%) on ITV2 from 10pm, the biggest multichannel audience of the night. A further 207k (2%) watched the show on timeshift. Skins entertained 332k (1.9%) on E4 from 10pm and 110k (1.2%) on +1.
BARB ratings data supplied by Attentional