Walters will play Emma Watts, a defence barrister who is fighting for Alan Lane (John Lynch), a man convicted of murdering three women he met on the internet. The Thick of It star Roger Allam will play the prosecution barrister John Mallory.
The show's focus is on the everyday people in the jury, who are caught up in a high profile trial which forces them to face up to the problems in their own lives.
Aqib Khan, Natalie Press, Steven Mackintosh, Jodhi May and Ronald Pickup will appear as the jurors.
ITV's Drama's Laura Mackie said: "Peter Morgan's original series in 2002 was a hugely popular state of the nation drama so we were delighted when he came up with a brand new, equally compelling case. Peter is one of the best writers in the country so we are delighted to have his work back on ITV1."
Kate Bartlett, ITV's creative director of drama added: "We are thrilled that Julie Walters will be playing defence barrister Emma Watts opposite Roger Allam's prosecution barrister John Mallory in Peter Morgan's drama that sees his return to television."
The Jury will begin shooting later this month and will air in five parts across a week in the autumn.