Kelly Reilly and Ciaran Hinds will reprise their respective roles as DI Anna Travis and DCS James Langton in the new three-part drama.
The new series, adapted by Lynda La Plante from her novel Silent Scream, will focus on the brutal murder of a glamorous British film star.
"I'm thrilled to be making a fourth series of Above Suspicion for ITV, which will see Travis progress even further up the career ladder investigating one of her most challenging cases to date," said La Plante.
ITV Drama Commissioner Laure Mackie added: "Above Suspicion has grown into a really strong brand for ITV1 and the fourth instalment, Silent Scream, is set to be another gripping story for Travis and Langton to investigate."
Back in 2009, the first series of Above Suspicion premiered to 6.76m viewers, while last year the final instalment of sequel The Red Dahlia attracted a slightly higher 6.85m.
Filming on Above Suspicion: Silent Scream will begin in the summer.
> Reilly teases Above Suspicion romance