The 55-year-old entertainer, who recently branded himself a "nosey so-and-so", also blasted the "addictive" nature of the social networking site.
He told Buzz: "After a few drinks I'd be on Twitter cursing people, then everything I'd ranted about would be all over the papers.
"No thank you! Also it's addictive. I've been out with friends who are tweeting each other even though they're at the same table.
"If you're already in the public eye, why would you want to tell everyone what you're doing every two minutes?"
The star's chatshow Paul O'Grady Live returns for a second run next Friday at 9pm, where his guests will be Amanda Holden, John Cleese, Charlotte Church and Rupert Everett.