Phillip Schofield will return to host the popular gameshow, in which contestants compete in various challenges to win a cash prize. Made by Objective Productions, the new series will begin filming later this year.
"The Cube has proved itself to be a firm hit with viewers," ITV's controller of entertainment John Kaye Cooper said. "We are delighted to commission this compelling gameshow for a fourth series."
Adam Adler, the show's creator, added: "We're delighted that The Cube has been recommissioned for a fourth series. We've got loads of ideas for exciting new games that people will be able to play both in the real Cube and in their living rooms across the country."
The third series premiered to almost 4 million viewers earlier this month.
An upcoming celebrity special will see McFly's Tom Fletcher compete, in what Schofield has teased as an "amazing" episode.
The Cube continues on Sunday at 6.30pm on ITV1.
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