Dara O'Briain will be back as host of the show along with regular panellists Hugh Dennis and Andy Parsons.
Show creator Dan Patterson said: "What a year 2011 has been. We've had a referendum, a royal wedding and the discovery of the world's most wanted man.
"Unfortunately, that's all gone now, but I'm sure we'll get just as much mileage out of the Turkish elections, the England v Sri Lanka Test Series and the effect of inflation on utility bills. We can't wait to get started."
Chris Addison, Micky Flanagan, Ed Byrne, Greg Davies, Milton Jones, Ava Vidal, Stewart Francis and Zoe Lyons will be among the guests during the series.
Mock the Week returns on Thursday, June 9 on BBC Two and will air for six weeks. It will then return for another half dozen shows in September and October, followed by a Christmas special.