Cash has directed the series, which is based around a family business in Weston-super-Mare, run by a mother, grandmother and daughter on the seafront. June Watson, Ellie Haddington and Michelle Terry take on the lead roles of Mary, Carol and Sarah.
Little, who has written the script with Michelle Terry (Reunited), plays Sarah's ex-boyfriend Richard who is a musician by night and care home worker by day. Daniel Ings is cast as successful events manager and former love rival John, who returns to Weston and ruffles some feathers.
David Troughton, Phoebe Waller-Bridge, Jack Roth, Kevin Trainor and Seeta Indrani are also among the cast.
Cash's previous award-winning TV credits include The Royle Family, Early Doors, The Mrs Merton Show and Sunshine.
Little and Cash last worked together on the 2010 Royle Family special 'Joe's Crackers'.
Lucy Lumsden, head of comedy at Sky, said: "It's been a delight to give new writers like Ralf and Michelle the chance to shine on Sky1. We look forward to welcoming you in to The Cafe with its amazing cast and stunning direction from the multi-talented Craig Cash."
"It's great to be working with Lucy Lumsden again. Sky has shown an unswerving commitment to this project, and our vision for it," said Cash. "Working with these writers, this script and this team has been a joy. A joy we hope to pass on the audience very soon."
The Cafe will run for six episodes on Sky1 in October.
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