The duo will present Lunch with Mel and Gino on weekdays throughout August as both This Morning and Loose Women go on their summer break.
Sykes previously hosted Today with Des and Mel with Des O'Connor for the broadcaster. However, the chatshow was scrapped in 2005.
Lunch with Mel and Gino will see the pair joined by two celebrity guests each day on a show which the broadcaster described in an official press release as "a fast-paced, live lunch hour centred around having fun with food".
"Gino and I are going to have an absolute blast. Bring on the summer!" Sykes said, while D'Acampo added: "It's going to be fantastico!"
The Italian chef, a regular on This Morning, triumphed in the 2009 series of I'm A Celebrity... Get Me Out of Here.
> Dannii Minogue in talks to join 'This Morning'