The talkshow host has landed the role on High Stakes, The Sun reports.
The show is described as a game of "knowledge, risk and tension".
Contestants, who can win £500,000, have to choose the right six steps on a grid and avoid certain numbers.
"I am hugely excited to be hosting this brand new quiz show," Kyle said. "It's a totally new format."
Earlier this year, ITV2 announced that it will broadcast the American version of Kyle's chatshow. The series is expected to begin in the US in September.