The Baby Cow founders' latest comedy project has been written by Peep Show and Whites actor Matt King.
Brendan Coyle and Lesley Sharp will play the mother and father of the Starling family, who have a crammed home following the return of their granddad.
The characters will include a 16-year-old football-crazy tomboy daughter, a reptile enthusiast son and beautiful daughter Bell, who gives birth in episode one.
Other characters invading the house will be Bell's ex-boyfriend Reuben, granddad's long-lost son Uncle Loz and nephew Fergie, who has just been made homeless by his long-suffering partner.
The Starlings is part of Sky1's new autumn lineup of shows, which is focussed on homegrown comedy.
Other new series include supermarket-based comedy Trollied, Joanna Page and Sue Johnston's Gates and Sally Lindsay comedy drama Mount Pleasant.