John Barrowman and Brian Conley joined panel regulars Kate Thornton, Sherrie Hewson and Denise Welch to give Nolan a final send-off from the ITV1 daytime show.
Nolan is quitting the talkshow after 11 years as one of its regular guests.
"I just want to say thank you to everyone obviously, all you girls [panellists]," she said in her final speech.
"I know we will be friends forever so it's not goodbye for us but to all the people that have been involved in the show backstage... thank you.
"But more importantly I want to thank you the audience and you at home because you have been through my life with me and you've stood by me for 11 years. You have made me what I am today."
Nolan added: "I'll never forget this show. It has been my life. It will always be my life and I'll always be grateful for it. I love every one of you and all of you at home."
Nolan ended the show with a performance of Carole King's 'Say Goodbye Today', which featured her husband Ray Fensome on guitar.
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