The programme features an audience full of would-be singers, stand-up comics and variety acts who are invited on to the stage to perform in an attempt to win £25,000.
However, every member of the audience also has a voting keypad and when over half have had enough of the performance the contestants will be ejected from the stage.
Trapdoors, bungees and exploding stages are all possible means of getting rid of the hopefuls, but if they survive the 100-second performance they could be in with a chance of winning the money.
Each week, a celebrity guest will join Byram to talk about the acts.
"I'm so thrilled to be a part of such a fun, exciting new talent show," Byram said. "We're hoping to find some serious talent along the way, but contestants be warned! One bum note or bad joke and your hopes and dreams of success will be literally swept away from you, with a dramatic departure from the show..."
Meanwhile, Sky1's head of entertainment Duncan Grey said: "Don't Stop Me Now is loud and funny and a little bit naughty. We think it'll be high impact, don't blink or you'll miss it viewing for our customers."
Byram has previously worked on shows including Total Wipeout, The Swan and The Big Breakfast.
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