The former Mock the Week comedian will front Frankie Boyle's Rehabilitation Programme for the broadcaster later this year.
Channel 4's head of comedy Shane Allen told The Guardian: "It's him in a studio. It's capturing him riffing off the audience a bit, with some people challenging what he says.
"We are just working out how we can best capture that. If Frankie has an opinion about a story, we'd have someone on who maybe had a connection to the story or was an expert."
Boyle will film a pilot of the show in October. If a full series is commissioned, each episode will be shot the night before transmission, which Allen claims will allow Channel 4 to "cut out all the horrific bits".
"It's very much like Parkinson or Wogan, but with paedo jokes," Allen joked.
Boyle caused outrage last year when he made a controversial joke about Katie Price's disabled son Harvey on his Channel 4 show Tramadol Nights. Ofcom later upheld Price's complaint over the "discriminatory, offensive, demeaning and humiliating" comments.
The broadcasting regulator received around 500 complaints about the series, including objections from disability charities Mencap and the Royal London Society for the Blind.
Allen went on to defend Boyle, adding: "Frankie is just a bit pissed off that he's portrayed as this one-setting shock machine. He's a very politically aware, bright bloke who wants to show his intellectual muscle a bit more."
Channel 4's chief creative officer Jay Hunt recently insisted that she would be happy to work with the stand-up comic again, despite making the decision not to recommission Tramadol Nights.
> Frankie Boyle voted 'most offensive'