The stand-up show's seventh series will air for eight 30-minute episodes from November and will feature some of the biggest names currently on the comedy circuit.
Flanagan will host the first episode with guests Seann Walsh and Jason Byrne.
Other hosts for the run of the series will include Whitehall, Carr, Jason Manford, Sarah Millican, Andy Parsons and Rich Hall.
Ed Byrne, Lee Nelson, Russell Kane, Mark Watson and Patrick Kielty are among the special guest comics lined up to perform.
Live at the Apollo is filmed in front of an audience of more than 3,500 at London's famous Hammersmith Apollo venue.
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