Six half-hour episodes will begin filming in front of a live audience in late November, the actor confirmed to Cult Box.
"We've gone back to our original format, for obvious reasons," said John-Jules, who plays Cat in the sci-fi comedy. "Everyone missed the studio audience bit."
Red Dwarf last returned to television in 2009 for three-part mini-series Back to Earth, which lacked a live audience.
"It's a different rhythm when you've got a studio audience and I like that," said John-Jules. "There's always that bit of fear that you're going to screw up the best gag in the show in front of the audience. It sorts the men out from the boys, let's put it that way."
The actor also insisted that he is happy to be working with Dave on the new Red Dwarf series, despite the comedy's BBC origins.
"The reason why it's on Dave is that the BBC said there's no audience for Red Dwarf anymore," he explained. "This is what we're up against.
"[But] we're quite happy - at the end of the day, the people who watch the show will decide whether it stays on telly or not. When a show gets three and a half million viewers on a cable channel, it's not rocket science!"
> Red Dwarf new series to shoot this year
Watch a classic Red Dwarf scene below: