Hosted by Bradley Walsh, the special run's first episodes will feature Strictly Come Dancing star Ann Widdecombe, presenter Eamonn Holmes and Coronation Street actress Michelle Collins.
Carol Vorderman, Blur's Alex James, Cold Feet actor John Thomson, Jenny Frost, Austin Healey and Sara Cox are also part of the early lineup.
Shaun Williamson, Ulrika Jonsson, Joe Pasquale, Janet Street-Porter and Nick Hancock will join the programme later on in the six-part series.
Barry McGuigan, Sally Lindsay, Jennie Bond, Paul Ross, Laurence Llewelyn-Bowen, Phil Tufnell, Mark Durden Smith and Jenny Éclair will also appear.
They will face general knowledge genius The Chaser in a race to win £1,000 for their chosen charities.
Celebrity Chase will begin on Saturday, October 29 at 6pm on ITV1.