The stand-up comedy show was the channel's highest-rating commission in 2010 and aired its second series in April.
Comedians who have appeared on the programme, where a headliner invites two other comics to perform at their hometown, have included the likes of Chris Addison, Dave Gorman, Mark Watson, Greg Davies and Jason Byrne .
Series three will feature Ardal O'Hanlon, Tim Vine, Reginald D Hunter, Stephen K Amos and Tommy Tiernan and starts tonight at 9pm on Dave.
Another comedy show to have recently returned to the digital station is Argumental, which has seen Robert Webb replace Rufus Hound as a regular team captain.
> Read our recent interview with Tim Vine
Watch a clip of Tim Vine on One Night Stand below: