The actor will join Ross on the ITV1 show on Friday, December 23 to talk about his new movie Mission: Impossible - Ghost Protocol, which opens in UK and US cinemas on Boxing Day (December 26).
Downton Abbey cast members Jessica Brown Findlay, Laura Carmichael and Michelle Dockery will talk about the costume drama's Christmas special on the show.
Ross's other guests include the cast of The Inbetweeners and comedian Tim Minchin, who will perform a specially composed Christmas song.
Italian teenage tenors Il Volo, who appeared on American Idol earlier this year, will also perform.
Ross recently confirmed that he will stay with ITV until 2013, saying that he is "thrilled" to have signed a new deal with the channel.
The first series of The Jonathan Ross Show averaged just over 4 million viewers per episode in its Saturday evening slot after The X Factor.
> 'Mission: Impossible - Ghost Protocol - 10 teasers for Tom Cruise's latest movie
Watch a trailer for Mission: Impossible - Ghost Protocol:
See a poster gallery for Mission: Impossible - Ghost Protocol below: