Mrs Biggs will focus on the life of the train robber's spouse from the moment they met on a train, Broadcast says.
The show's executive producer Jeff Pope, who has reportedly been developing the project for four years, described it as "one of the greatest untold stories of the 20th century".
Charmian Biggs has also been working on the five-part series as a consultant.
Filming for Mrs Biggs, which is being co-produced by an Australian company and will air there on the Seven Network, will take place in London, Paris, Melbourne and Rio de Janeiro.
Pope recently worked on another ITV1 drama, the critically acclaimed Appropriate Adult, which starred Dominic West and Emily Watson.
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