Retitled Scream Extreme: USA, the show has moved to Six Flags Magic Mountain in America and is now a co-production with The Travel Channel.
Celebrities confirmed for the series include Gavin & Stacey star Sheridan Smith, Strictly duo Craig Revel Horwood and Bruno Tonioli, and US reality TV regulars Coolio, Stephen Baldwin and Corey Feldman.
Original 90210 actress Shannen Doherty is also signed up to take part.
Blue's Duncan James continues as host and Radio 5 Live DJ Colin Murray is back as the commentator for the high-octane challenges, which feature celebrities partnering civilian contestants on rollercoaster challenges.
Watch's general manager Steve Hornsey said: "We've really upped the ante in this series with bigger, scarier and seriously stomach-churning rides. The combination of US and UK celebrities, bravely attempting to answer questions on rides that deliver forces of up to 5Gs, will give Watch an exclusive, stand-out show."
The return of Scream coincides with Watch's investment in US acquisitions Alcatraz and Grimm, and the recommissioning of Dynamo's award-winning magic series.
Watch a video of Digital Spy's Mayer Nissim taking part in Scream If You Know The Answer! below: