Don't Stop Me Now is Sky1's attempt to provide a talent show with a twist as the entertainment derives from "getting rid of the dross" rather than sob stories, nasty judges and video montages.
Hosted by Amanda Byram, the series will feature singers, comedians and variety acts performing for a studio audience in the hope of winning £25,000.
However, if they get voted off the show, the act will be literally ejected from the studio. Methods of exit include horizontal bungees, exploding stages and trap doors.
Moyles and Harding are among a list of celebrity commentators who will join Byram on the programme.
Freddie Flintoff, David Haye, Got to Dance duo Kimberly Wyatt and Ashley Banjo, Micky Flanagan, Louie Spence and Sally Lindsay are among the other stars lined up to appear.
Byram said: "I'm so excited for Don't Stop Me Now to hit the screens! It was so much fun filming what I call a 'talent show with a twist, crash bang and wallop!' We found some very unique and fantastic talent along the way, while others had their dreams left in tatters as they were quite literally 'swept' off the stage."
> Amanda Byram to host Sky1 gameshow Don't Stop Me Now