Soap actress Samantha Womack, Coronation Street star Antony Cotton and Benidorm comic Steve Pemberton will appear in the quiz show special.
All three will be joined by their mums as they take on the Chris Tarrant-hosted quiz and attempt to earn big cash prizes for charities of their choice.
"I've been secretly hoping that I'd get asked to go on Millionaire so it's brilliant to now be taking part with my mum on Mother's Day," said Pemberton.
"I'm not sure she'll answer many of the questions but she's definitely going to be good value for money! I'm also watching as many quiz shows as I can in preparation for the general knowledge questions but the hardest thing is choosing your 'phone a friend', you have to pick them wisely!"
Womack commented: "I'm really excited about appearing on the show but not so excited about having to negotiate with my mother on live TV!"
I'm A Celebrity star Cotton added: "I am excited and terrified in equal measure!"
Celebrity Who Wants to Be a Millionaire: Mother's Day Special airs on Sunday, March 18 at 8.30pm on ITV1.
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