James Corden will continue to host the sports quiz, alongside team captains Jamie Redknapp and Freddie Flintoff.
Comedian Jack Whitehall will also join the show as a regular panellist for the new run.
John Bishop will appear in four episodes, while David Walliams, Jimmy Carr, Micky Flanagan, Christine Bleakley, Gabby Logan, Claudia Winkleman and Zoe Ball will all guest.
Sports stars featuring in the new series include footballers Steven Gerrard, Peter Crouch and Joe Hart, plus athletes Jessica Ennis and Mo Farah.
The series will consist of eight 60-minute shows and two special hour-long 'Unseen' episodes.
A League of Their Own returns to Sky1 in April.
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Watch a clip from the last series of A League of Their Own below: