Fake Reaction will see six celebrities battle to hide their natural reactions as they face an array of unusual situations, round-by-round.
If each guest can conceal their true feelings and fool the rest of the panel, they win the round.
STV Productions will produce the quiz, which is based partly on a Fuji TV game show format.
T4 host Edmondson will present a full series, following successful run-throughs featuring comedian Chris Ramsey, musician Skepta and Harry Potter actress Jessie Cave.
"Matt is a terrific talent whose rapier sharp wit really brought a funny and inventive format to life," said the BBC's Alan Tyler. "We're delighted to be working with STV on the pilot."
STV Productions developed the Fake Reaction format with LA-based production company Kinetic Content. The series will be filmed next month at Pacific Quay in Glasgow.
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