The two series of the cult show originally ran in 1996 and 1997, and the cast reunited in 2007 for one-off special This Life + 10.
Asked if there would ever be another revival, Davenport told Metro: "No. It was a nice little coda to check in with those characters ten years on but I don't think there's a need to do it again.
"We were delighted to do it but knew the press would hammer it. We knew we'd be battered for the slightly Spinal Tap aspect of reforming but people wanted to see it."
He added: "It was a gift to the people who loved it the first time round rather than those who wanted to hammer it because it wasn't exactly the same."
Since the show finished, Davenport has appeared in FlashForward and Smash, while his co-star Andrew Lincoln leads AMC's adaptation of The Walking Dead.
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Watch a This Life trailer starring Jack Davenport below: