BBC One's 22-year-old satirical panel show, starring Paul Merton and Ian Hislop, won an average of 5.3m (23%) at 9pm.
Piers Morgan's Life Stories interview with Frank Bruno - coinciding with his reported bipolar relapse - attracted 3.96m (17.3%) to ITV1 (+1: 294k/1.4%).
Lee Mack's Not Going Out amused 4.16m (18.4%) on BBC One at 9.30pm, and Graham Norton rounded off the night at 10.35pm with 3.32m (22.8%).
Would I Lie To You? held 3.4m (14.5%) at 8.30pm, while ITV1's Poms and Paradise took 2.84m (12.8%) at 8pm (+1: 105k/0.5%).
Mastermind (2.15m/9.7%) and Gardeners' World (2.35m/10%) both rallied for BBC Two in the 8pm hour, then 1.22m (5.3%) watched Brick By Brick, and Twenty Twelve entertained 1.03m (5.4%).
The Million Pound Drop logged a solid 1.65m (7.7%) for Channel 4 between 9pm and 10.45pm, adding 233k (1.4%) on timeshift.
Meanwhile, Eddie Stobart: Trucks and Trailers delivered 1.13m (4.9%) to Channel 5 at 8pm (+1: 152k/0.9%), then The Mentalist grabbed 1.42m (6.2%) from 9pm (+1: 152k/0.9%).
Overall, ITV1 topped primetime with 21.9% (+1: 0.8%) against BBC One's 20.7%. BBC Two finished in third place with 7.1%, ahead of Channel 4's 5.2% (+1: 0.7%) and Channel 5's 4.4% (+1: 0.3%).
James Corden's sports quiz show A League of Their Own returned with 567k (2.5%) for Sky1.
BARB ratings data supplied by Attentional