The CNN anchor's Carol Vorderman interview interested 4.43m (19.1%) on ITV1 in the 9pm hour, adding 243k (1.3%) an hour later on +1.
Have I Got News For You, meanwhile, averaged 4.67m (20.2%) for BBC One between 9pm and 9.30pm, a drop of over 600,000 viewers week-on-week.
Lee Mack's Not Going Out maintained a respectable 4.06m (17.6%) at 9.30pm, then The Graham Norton Show entertained 3.3m (22.8%) from 10.35pm.
Would I Lie To You? amused 3.15m (13.8%) at 8.30pm, while ITV1's respective 8pm filler Poms and Paradise picked up 2.94m (13.3%).
Channel 4's new spring comedy night made a slow start: 8 Out of 10 Cats kicked off with 1.11m (4.8%) at 9pm (+1: 202k), after which 1.05m (4.5%) stuck around for brand new sketch show Very Important People at 9.30pm (+1: 188k/1.1%).
Anchoring the 10pm slot, Alan Carr: Chatty Man attracted 1.65m (9.2%) and 223k on timeshift, the network's highest audience of the night.
BBC Two fared much better, with its Mastermind (1.84m/8.3%) and Gardeners' World (1.98m/8.7%) combination coming up trumps as usual in the 8pm hour.
John Le Mesurier documentary It's All Been Rather Lovely was seen by 2.2m (9.5%) at 9pm, before QI quizzed 2.46m (12.3%) at 10pm.
The Mentalist led Channel 5's evening with 1.41m (6.1%) at 9pm, while Dirty Great Machines mustered 999k (4.5%) an hour earlier.
Overall, ITV1 topped primetime with 21.9% (+1: 0.8%), ahead of BBC One's 19.4%. BBC Two claimed third place with 8.8%, followed by Channel 4's 5.1% (+1: 0.7%), and Channel 5's 4.1% (+1: 0.1%).
A League of their Own scored 447k (1.9%) on Sky1, down slightly on its premiere last week.
BARB ratings data supplied by Attentional