The BBC Three sitcom starred Will Mellor as Ollie, who reluctantly takes over the family handyman business when his father falls ill.
Series creator Adrian Poynton confirmed the cancellation to The British Comedy Guide, claiming that BBC Three "wants to take its comedy output in another direction".
"It's a strange place to find ourselves really," he said. "We honestly believe we made a second series bigger, bolder and stronger than series one and audience reaction seemed to back that up.
"The final episode of the series is a great way to end the show, although I did have a few more stories I wanted to tell... and a few final things to wrap up for the regular viewers."
Earlier this year, Will Mellor told Digital Spy that he was expecting a third series of White Van Man to be commissioned.
"We're already story-lining [series three] so we're definitely heading towards that," he said in February.
A US remake of the show - starring Kyle Bornheimer, JK Simmons and Leah Remini - is currently in development at ABC.
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Watch a clip from series two of White Van Man below: