Host Bradley Walsh will film a US version of the programme next week, when Fox will fly American contestants to the UK studios.
Producers hope Walsh will follow in the footsteps of Jeremy Kyle, Piers Morgan and Anne Robinson to become a big name Stateside.
"This is the big time for Bradley now. It could be huge," a source told The Sun.
"Telly is a big deal in America and they love Brits - look at Anne Robinson, Piers Morgan. Even Jeremy Kyle and Gordon Ramsay have made the big time."
The Chase sees four contestants work as a team to amass as much money as possible, before battling against a quiz genius known as The Chaser to take the money home.
It has not yet been decided if the UK Chasers - Mark Labbett, Shaun Wallace, Anne Hegerty and Paul Sinha - will star in the US version.