The BBC has confirmed that the satirical panel show is to return for a five-part 11th series on June 14, with the landmark episode airing on July 5.
Six more episodes will be broadcast on BBC Two from September to October and a Christmas special will also be produced.
Host Dara O'Briain and regular panellists Andy Parsons, Hugh Dennis and Chris Addison will all return for the new series.
Comedians Micky Flanagan, Greg Davies of The Inbetweeners and Nathan Caton are guests for the first episode back, while the likes of Milton Jones, Marcus Brigstocke, Zoe Lyons and Miles Jupp will feature on the summer series.
Ed Byrne and Stewart Francis are among the famous faces booked for episodes later in the year.
Mock the Week first aired in June 2005 when Prime Minister David Cameron was a largely unknown Shadow Education Secretary and Nick Clegg and Ed Miliband had only been MPs for four weeks.
Watch a classic Mock the Week clip below:
Watch Russell Howard discuss his Good News series with Digital Spy below: