The series will be ITV1's first daytime drama in four years, and is produced by the makers of The Bill.
It will comprise 20 hour-long episodes, and will be recorded at The Bill's former home at Wimbledon Studios. The drama follows two police officers taking on cases inspired by real events.
True Crime is created by former Bill executive Paul Marquess of Newman Street, a newly formed drama division at FremantleMedia UK.
The show will be shot in a documentary style and will also contain footage similar to CCTV for an authentic look.
ITV's director of factual and daytime Alison Sharman said: "It's very confident and sassy, and there's definitely some grit in the oyster.
"We tested the pilot with our viewer panel and we came back with positive responses from younger and older viewers. We know that drama repeats fare well on ITV1 in the afternoon, but there's the opportunity to do something fresh and challenging."
True Crime will air on ITV1 in an afternoon slot later this year.
ITV axed The Bill after 27 years in 2010.