Clunes appeared alongside Neil Morrissey, Caroline Quentin and Leslie Ash in the series, which ran on ITV and later the BBC between 1992 and 1998.
Asked if he could see Men Behaving Badly returning to TV, the 50-year-old argued that the lad culture present on the show would make for uncomfortable viewing nowadays.
"To be perfectly honest, the others haven't aged as well as I have so I think it would be a bit unfair," he joked to the Radio Times. "It would all be a bit too seedy."
Clunes revealed in 2008 that a planned Men Behaving Badly reunion was scrapped because Quentin "suddenly felt quite strongly" against it.
The actor has said in the past that he still holds "fond memories of the show" and remains close friends with his co-stars.
Watch the Men Behaving Badly intro below: