The comedian will front the Boyle Variety Performance as part of Channel 4's Funny Fortnight.
The show will include a mixture of comedy, celebrity guests and other variety elements.
A spokesman said: "The Boyle Variety Performance is Frankie's unique take on a royal variety event.
"The show will come direct from a London theatre and feature content so cutting-edge and scurrilously funny that no self-respecting royal would dream of attending."
Vic and Bob will also host a new panel show Lucky Sexy Winners, that will feature new sketches and characters with "several unexpected anarchic twists along the way".
Father Ted's Arthur Matthews latest series Toast of London will premiere, along with Outnumbered creators Guy Jenkin and Andy Hamilton's new sitcom Just Around the Corner.
Morgana Robinson, Kayvan Novak, Sally Phillips and Blake Harrison will also star in a new sketch show Them from That Thing.
Harry Hill also returns to host a reunion programme, while Peter Kay will front a new stand-up show.
Channel 4's head of comedy Shane Allen said: "Funny Fortnight is a chance to celebrate our achievements with a raft of new shows featuring many of the biggest names in British comedy."