The comic revealed the news on his blog, adding that he is planning to focus on new projects such as a full series of Channel 4's Derek.
"So I don't think I'm going to do a fourth series of The Ricky Gervais Show," wrote Gervais. "39 episodes is more than I've ever done for any other project (Yes. I know that's pathetic but trust me.) and I don't want to push my luck.
"I think the show has steadily grown in both quality and popularity and I'd love to go out on a high so to speak. My worry is that as we've used up all the best material [from the original podcasts, so] we'd have to record hours and hours of new stuff and it might ruin the naivety of the whole thing. Never say never though."
Gervais explained that he and Karl Pilkington have also decided to wrap up comedy travel show An Idiot Abroad following two final specials.
"I think these could be the funniest adventures yet and I'd hate to outstay our welcome," he said.
The blog also stated that the Office and Extras star had "just finished writing the finale special" of BBC Two comedy Life's Too Short.
The Warwick Davis sitcom was expected to return for a second series, but it is currently unclear if Gervais also plans to wrap up that project.
"We'll film [the finale] after Xmas ready for broadcast around Easter," he wrote. "It's got lots and lots of Les [Dennis], Shaun [Williamson] and Cheggars!"
Gervais confirmed that he will now focus on a series of filmed audiobooks with Karl Pilkington, as well as six more episodes of Derek.
"[Derek] is my new baby, I must admit," he continued. "I've never been so in love with a project or character."