Scott, who won a BAFTA for his role as the villainous Moriarty in the BBC's Conan Doyle reboot, will star alongside Julia McKenzie, Charlotte Riley, Gerard Kearns, Kelly Adams and Martin
Clunes in this new three-part contemporary drama.
Penned by Laurence Olivier award-winning playwright Mike Bartlett, The Town follows the story of 30-year-old Mark Nicholas (Scott), who returns to his hometown Renton after 10 years away and he is drawn into the life he left behind.
Julia McKenzie stars as his grandmother Betty, Charlotte Riley plays his first love Alice, who is now married with a child, and Martin Clunes is the alcohol-soaked mayor Len.
"Mike Bartlett is a hugely exciting new talent and I'm delighted that ITV has commissioned his first project for television," said ITV's drama commissioner Laura Mackie.
"His characters are real and instantly engaging and his dialogue is natural and funny even in the darkest of moments."
Co-executive producer Kenton Allen added: "At the heart of The Town will be a family struggling to come to terms with change. It's also our hope to paint a picture of contemporary Britain through the magnifying glass of an ordinary market town.
"The story takes place in a landscape familiar to most of the UK. Most of the population live their lives in a place like Renton."
The Town has begun filming in High Wycombe.