The stand-up, who portrayed headmaster Mr Gilbert in The Inbetweeners, will play a teacher who hates his job in Man Down, reports The Sun.
Channel 4's comedy commissioning editor Nerys Evans said: "Greg is in more ways than one a giant of British comedy.
"He has managed to write a joyfully funny, laugh-out-loud script. We're thrilled to be working with him on his first solo piece."
Jon Thoday of Avalon, which will produce the show, added: "We are very excited to be part of bringing Greg's brilliant comic creation to Channel 4."
Davies will soon embark on a nationwide stand-up tour entitled 'The Back of My Mum's Head'. The comic's previous tour 'Firing Cheeseballs at a Dog' was extended three times and released on DVD last year.
He is also due to star opposite former Saturday Night Live performer Andy Samberg in BBC Three sitcom Cuckoo.
Watch Greg Davies's 'Firing Cheeseballs at a Dog' interview with Digital Spy below: