The Poison Tree will follow Karen Clarke (Buring), a haunted woman who goes to extraordinary lengths to protect her family.
After encountering the glamorous Biba (Ophelia Lovibond) and her handsome brother Rex (Watchmen actor Goode), Karen is drawn into their "tragic family history" and their "long summer of love" soon becomes a "nightmare".
The two-part drama - based on the novel by Erin Kelly - has been written by Emilia di Girolamo (Law & Order: UK).
"We are delighted to be working with STV and Emilia di Girolamo on this intriguing and emotional thriller," said ITV's Steve November. "Erin Kelly's novel is rich and absorbing and is perfectly suited to ITV."
Margaret Enefer - Head of Drama for STV Productions - added: "We are thrilled to be bringing this dark and bewitching psychological thriller to life on screen for ITV1. We're certain it will grip viewers from start to finish."
The Poison Tree will enter production this summer and will air on ITV1 later this year.