Speaking at the Edinburgh TV Festival, Hadlow claimed that "controversy" came hand-in-hand with taking risks, which she said was an intrinsic part of BBC Two's remit as a channel.
When asked about Life's Too Short, Hadlow said: "I think part of BBC Two's remit is to take risks. Are you brave enough and are you willing to take risks as a channel?
"If you want to take risks, which we do, you will do things that cause controversy."
She added: "I think you judge it in the end on whether people will laugh or not."
Hadlow said that she was happy with the broadcaster's post-watershed slate of comedy with hits such as Rev and Twenty Twelve, but revealed that a "broader, pre-watershed show" was a big concern following the shift of Miranda to BBC One.
Hadlow announced a string of new shows at the Edinburgh Festival, including a reunion for Bottom duo Rik Mayall and Adrian Edmondson and a new comedy drama from Mitchell and Webb.