The eight-part programme is set in South-East London and follows a group of friends trying to negotiate their way through teenage life and launch a music career.
Youngers will mainly focus on the characters Yemi - an honour student and aspiring producer - and Jay, who enters a local music competition after failing his GCSEs.
YouTube stars Mandem On The Wall, individually known as BRIT school graduates Jovian Wade, Percelle Ascott and Dee Kartier, will appear alongside new talent spotted at open auditions attended by 350 actors, rappers and aspiring music artists aged 16-19.
Youngers has been written by Levi David Addai (My Murder), Georgia Lester (Skins) and Mark Catley (Casualty).
Documentary maker Anthony Philipson, whose previous work includes 24 Hours in A&E and Coppers, will make his drama directorial debut on the show.
"Youngers is a very exciting project for E4," said commissioning editor for Channel 4 Drama Sophie Gardiner.
"Levi David Addai has written something utterly contemporary, witty and warm, which offers an insight into the lives of teenagers who have dreams and talent - a view of a world we don't often see."
Executive producer Luke Alkin added: "British urban music has gone mainstream but artists like Dizzee Rascal and Tinie Tempah were just like Jay and Yemi a few years ago, making music in their bedrooms and showcasing it on the internet.
"Levi David Addai captures this world in an incredibly fresh, funny and positive way. His characters are inner-city teenagers with dreams and ambitions for the future - and this is what makes Youngers feel so original and exciting."