The former Doctor Who star will present Comedy World Cup, the channel's controller Jay Hunt announced at this year's Edinburgh International Television Festival.
The seven-part series will follow teams of comedians as they use their stand-up routines to avoid being ejected from the competition.
Tennant's other forthcoming projects include ITV crime drama Broadchurch and BBC Two's political mini-series The Politician's Husband.
The Scottish actor is also rumoured to be making a return to Doctor Who for the show's 50th anniversary in 2013.
"I'm sure there are lots of plans being discussed," he hinted earlier this month. "I am not confirming nor denying anything."
> Edinburgh TV Festival Live Blog: Jay Hunt on future of Channel 4
> Big Fat Gypsy Weddings coming to an end in 2013, confirms Channel 4