The long-awaited TV show will feature celebrities and ordinary people testing illegal substances, and is intended to launch a discussion on the impact of drugs on individuals.
"Half a million people a year are quite regularly taking ecstasy," said Hunt at the Edinburgh TV Festival.
"We're having an intelligent conversation about what the impact of that is going to be.
"It will air this autumn and it's been quite a journey getting there. I was very tempted to make a show called The Making of Drugs: Live."
The C4 controller confirmed that the show would involve Keith Allen and members of the public, such as a female vicar, taking MDMA.
"It will be a weird and eclectic bunch of people," she said.
Hunt also revealed that large chunks of the show would have to be pre-recorded because of the requirement to do blind testing.