Science Club will feature reporters and expert guests exploring fascinating facts and tackling unexpected questions.
Each week, the team will take a subject, such as extinction, Einstein, space exploration or sex, and examine it from various angles with in-depth studio discussion, films and on-the-spot reports.
Example topics include: 'Did you know that the bicycle has done more to improve the human immune system than any other invention in history?', 'Are computers ruining music?' and 'Do smart drugs really make you brainier?'.
O'Briain, who has a degree in mathematics and theoretical physics, will be joined by materials scientist and engineer Mark Miodownik, neuroscientist Tali Sharot, physicist and oceanographer Helen Czerski and journalist Alok Jha.
O'Briain said: "I'm very excited to be opening the doors to my brand new Science Club on BBC Two. It's for anyone who, like me, is curious about space, brains, extinction and sex and all the great ideas about how the universe works.
"And if that doesn't grab you, we'll show you how to measure the speed of light using cheese on toast or find your DNA with strong Polish vodka."
Dara O'Briain's Science Club will air on BBC Two in early November.
Watch a trailer for O'Briain's previous School of Hard Sums below: