The comedian will front a new series and a Christmas special of The Last Leg, the late-night talk show that originally ran daily as part of the broadcaster's Paralympics coverage.
Hills will once again be joined by Alex Brooker and Josh Widdecombe. The new series will air next year.
Entertainment Commissioning Editor Syeda Irtizaali said: "We knew The Last Leg was something special and we were in no doubt we wanted to keep the show's spirit of open and frank debate alive.
"We are working on a number of great ideas that will help push the show forward from its Paralympic origins into a broad, intelligent and entertaining series. I'm hugely looking forward to working again with Adam, Alex and Josh."
Copyright: PA Images David Davies/PA WireHills added: "The Paralympics is one of my favourite events in the world. When Channel 4 offered me the chance to cover it with The Last Leg, I jumped at it.
"It's not often you get the chance to do something you absolutely love, that people seem to connect with. I thought The Last Leg was going to be a once-in-a-lifetime opportunity. I'm over the moon to think that we can do it all again. "
Channel 4 will also air one of Hills's live stand-up shows, which which was recorded in December at the Lyric Theatre in London's West End.