Mankind: The Story of All of Us premieres on History on Wednesday, November 14 at 10pm.
Fry said of the show: "Just when you thought you knew it all, along comes a fantastic series, which throws a whole new and surprising light on the events that shaped our survival on this planet.
"I'm delighted to be part of such an exciting and epic project that explores through geology, astronomy, meteorology and physics the forces of nature that have shaped the story of mankind."
"His intelligent and engaging delivery is a perfect match for the programme's storytelling. This epic television series will look at the history of the human race through the ages in a way that is highly ambitious in the scale of its cinematic vision and dramatic reconstructions of the most critical events in human history."
Jane Root, CEO of producers Nutopia, said: "Mankind: The Story of All of Us will redefine history - the series takes a completely new look at who we are and where we came from.
"I believe it will fundamentally change the way we view the world forever. Who better to take viewers on this spectacular journey of exploration than the multi-talented Stephen Fry, who has a thirst for knowledge, science and discovery that is infectious and unrivalled."