A decade on and the show is arguably as strong as it's ever been thanks to the smart idea of not replacing Deayton with a like-for-like replacement and instead opting to employ a rolling door policy on celebrity guest hosts.
Have I Got News for You's most memorable guest hosts - Pictures:
Ian Hislop and Paul Merton since Deayton left. Tonight's episode (hosted by Homeland's Damian Lewis) marks the 10th anniversary of guest presenters.
Some of the most memorable guests include Bruce Forsyth, who helped revive his career with his sparkling appearance, which had Paul Merton in stitches (who can forget 'Play Your Iraqi Cards Right'?), Ann Widdecombe, who almost walked out, and Rolf Harris, who brought his own stylophone.
Tom Baker, a booming Brian Blessed and William Shatner have brought some surreal moments, while a whole plethora of politicians have attempted to mimic the success of Boris Johnson and showcase their softer side and funny bone. Some have succeeded. Others have fallen flat on their face.
Have I Got News for You airs tonight (November 9) at 9pm on BBC One.