The reunited girlband will perform on the December 14 edition of the Irish host's chatshow, which will also feature interviews with Freeman, Oscar winner Emma Thompson, Dawn French and comic Lee Mack.
Sherlock star Freeman is booked to talk about his role in the new Hobbit movie.
Other upcoming guests appearing with Norton include Harry Potter star Daniel Radcliffe, Olympic gold medal winner Jessica Ennis and popstar Bruno Mars.
The November 30 show will star Jake Gyllenhaal, Joan Rivers and Top Gear's Jeremy Clarkson and James May.
This Friday's guests include Helena Bonham Carter, Jack Whitehall and Michael Palin. Michael Buble is the musical guest.