Celebrating its 18th year, Dermot O'Leary returns to host this year's ceremony at London's O2 Arena on Wednesday, January 23.
Newcomers at the awards for 2013 include BBC Saturday night hit The Voice UK and cult hit The Great British Bake Off.
The biggest battle of the evening comes in the 'Talent Show' category where Simon Cowell's X Factor and Britain's Got Talent reignite their battles with the BBC's Strictly Come Dancing and The Voice.
Ant & Dec will be aiming to secure the 12th consecutive NTA for 'Entertainment Presenter', battling this year against Alan Carr, Dermot O'Leary and Celebrity Juice star Keith Lemon.
The highly-regarded 'Best Drama' category will see heavyweights Downton Abbey, Sherlock, Doctor Who and Merlin facing off for the title.
Doctor Who stars Matt Smith and Karen Gillan will also be hoping to reclaim their best actor and best actress crowns, but will face stiff competition from Mrs Biggs stars Sheridan Smith and Daniel Mays and Sherlock's Benedict Cumberbatch.
Meanwhile, the 'Best Sitcom' category will feature old favourites Absolutely Fabulous and Benidorm squaring up with Mrs Brown's Boys and E4 US import The Big Bang Theory.
A new category has been created for 'Documentary Series' this year, which will feature shows such as Frozen Planet and Planet Earth.
There will also be a special Landmark award in recognition of London 2012, celebrating the UK's greatest Olympics in over 100 years and honouring key members of the Olympic and Paralympic teams.
During the ceremony, viewers will be able to vote in the 'Serial Drama' category to crown either EastEnders, Coronation Street, Emmerdale or Hollyoaks the best soap on the box.
The National TV Awards air live on January 23 on ITV. Fans can vote for their favourite shows now on the NTAs website.