The three-part legal thriller has been written by Spooks creator David Wolstencroft.
Former Doctor Who star Tennant will play Will Burton, a talented junior barrister who has earned the nickname 'The Escape Artist' for his skill in getting his clients out of tight legal corners.
But when Burton acquits the prime suspect in a horrific murder trial, he finds that his brilliance comes back to bite him with unexpected and chilling results.
Toby Kebbell (RocknRolla), Sophie Okonedo (The Slap) and Ashley Jensen (Extras) will also star in the new drama, directed by Brian Welsh (Black Mirror).
[Left: Toby Kebbell, Right: Sophie Okonedo]
Producer Hilary Bevan Jones said: "The outstanding cast we have assembled, which is headed by David Tennant, Toby Kebbell, Sophie Okonedo and Ashley Jensen, is a testament to David's breathtaking and original script.
"Directed by Brian Welsh and produced by Paul Frift, I believe The Escape Artist will be one of the most anticipated TV drama events of 2013."
Wolstencroft added that The Escape Artist will get into the "blood and guts" of the legal system.
"I wanted to write a thriller set in the legal world that's as much about those primal feelings as it is about the twists and turns of the case," he explained.
"David Tennant is one of the most accomplished and iconic actors of his generation. I cannot wait to see him in Will's shoes."
> David Tennant, Arthur Darvill team up for ITV drama Broadchurch
> David Tennant to play Richard II in Royal Shakespeare Company return